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Title   고용량의 Cisplatin 병합화학요법시 급성 진토효과에 대한 Granisetron 과 Metoclopramide , Dexamethasone , Lorazepam 병용요법의 비교 ( A Comparison of the Acute Antiemetic Effect of Granisetron with Combination of Metoclopramide , Dexamethasone and Lorazepam in Patients Receiving High
Publicationinfo   1996 Jan; 028(03): 582-589.
Key_word   Granisetron, Cisplatin, Emesis
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Abstract   Granisetron, a 5-hydroxytryptamine3(5-HT3) receptor antagonist, is effective antiemetic agent in the control of cisplatin-induced emesis. We compared the efficacy and safety of granisetron with those of intravenous high-dose metoclopramide(1.5 mg/kg, four times) plus dexamethasone(10 mg i.v.) and lorazepam(2 mg i.v.)(MDL therapy) to control the acute emesis induced by high-dose cisplatin(>60mg/§³) treatment. Granisetron was injected in dose of 3 mg intravenously as recommended schedule for the prophylaxis of acute cisplatin-induced emesis. Granisetron was effective as MDL therapy for controlling of acute emesis. Of 25 granisetron-treated patients, 18(72%) were complete or major responders compared with 19/25(76%) patients who recieved the MDL therapy on first day of chemotherapy(P> 0.05). Also, in controlling of nausea, granisetron results were similar to MDL therapy. Side effects attributable to MDL group were sedation(60%)(P<0.01) and dizziness(20%)(P<0.05). In contrast to, headache(20%) of the granisetron group was higher than that of MDL group(P<0.05). Granisetron was effective as MDL therapy for controlling of the acute em esis and nausea induced by cisplatin. But, granisetron was more feasible and safer than MDL therapy.
저 자   신원용(Won Yong Shin),박성규(Seong Gyu Park),전진우(Jin Woo Jeon),원종호(Jong Ho Won),,백승호(Seung Ho Baik),오도연(Dae Sik Hong)홍대식(Dae Sik Hong),박희숙(Hee Sook Park)